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In a meta-analysis study, Notarte et al

The Ca2 + ATPase activity in the cell membrane is also inhibited by the Ca 2+ overload caused by Cd, which ultimately results in irreversible cell death

Jain N, Thompson P, Burger J, Borthakur G , Bose P, Estrov Z, Ferrajoli A, Takahashi K, Garg N, Wang X, Gandhi V, Plunkett W, Kanagal-Shamanna R, Patel K, Lopez W, Kantarjian H, O'Brien S, Keating M, Wierda W